What Is PDRN?

PDRN (Polydeoxyribonucleotide) is a purified DNA fragment chain, typically sourced from salmon. In regenerative and aesthetic medicine, it is prized for its ability to accelerate tissue repair, stimulate cell renewal, and enhance the skin’s natural recovery processes, all with a high level of safety and tolerance.

How PDRN Works in Skin Regeneration 

Once delivered into the skin, PDRN binds to specific adenosine receptors on fibroblasts and endothelial cells. This activates several pathways

• Encourages fibroblast proliferation, boosting collagen and elastin production.
• Increases VEGF, improving microcirculation and oxygenation.
• Reduces pro-inflammatory cytokines, creating a balanced healing environment.
• Moderates enzymes that break down collagen, helping maintain the skin’s structural integrity.

The result is stronger, smoother, and revitalised skin.

Proven Benefits of PDRN Treatments

✅ Speeds Up Skin Healing — Supports faster recovery after procedures and aids wound and scar healing. ✅ Promotes Collagen and Firmness — Stimulates fresh collagen, improving skin’s density and elasticity. ✅ Deeply Hydrates and Refines Texture — Enhances moisture retention and smooths the skin’s surface. ✅ Soothes Inflammation — Minimises redness and irritation, especially useful for sensitive or aged skin. ✅ Safe and Biocompatible — Its high purity and natural origin make it suitable for repeated treatments.

Where You’ll Find PDRN in Aesthetics

PDRN is a hero ingredient in modern biorevitalisers such as md:ArchiTech AUREALUM Lips & Face Rebuild, where it works alongside hyaluronic acid and niacinamide to restore lost volume and boost skin quality. It is also used in protocols for scars, stretch marks, and general skin rejuvenation, often combined with microneedling or mesotherapy to enhance results.