London, UK - February 19, 2013
Combination of chemical peels and topical depigmentation ingredients FOR the effective and SAFE treatment of melasma.
The treatment of hyperpigmented lesions, like melasma, is one of the biggest challenges to health care professionals and requires a correct training of all involved in skin care treatment.
Melasma is an acquired hyperpigmentary disorder that predominantly affects sun-exposed facial women skins. Lesions may present as tan, brown, blue, or black macules and patches in the centrofacial, malar, or mandibular regions. Multiple factors are involved in the aetiology and pathogenesis of melasma, including sun exposure, genetic predisposition, pregnancy, oral contraceptives and hormone therapy.
At first glance, the effects of skin hyperpig¬mentation disorders may seem purely cos¬metic in nature, but they also can have a severe psychological impact on patient quality of life, especially when located on the face, causing great emotional distress.
Various modalities are advocated for the treatment of melasma and yet it remains reversible and refractory in many instances. Lesions are difficult to remove and recurrence is a frequent problem. Prolonged treatment is required to control this condition.
Several topical treatments including Kojic acid, Retinoids, Glycolic acid, Alpha arbutin… are available for treatment with variable results. Although melasma treatment remains difficult, there are some therapeu¬tic options that could lead to improvement in both the cosmetic appearance of the skin and the quality of life of patients suffering these psychologically distressing conditions. The goal of therapy is to reduce the level of pigmentation without significant irritation or unwanted hypopigmentation.
The use of a novel therapy combining the application of topical depigmentation agents with series of in-office professional chemical peels (every two-three weeks) has reported excellent results in the removing of skin hyperpigmentations of melanic origin. The rapid visible improvements achieved with chemical peels encourages better lifelong adherence to outpatient regimens, producing better results than that achievable with at-home regimen alone.
Chemical peels such as Azelaic, Pyruvic, Mandelic, Salicylic…have been used as exfoliating agents to increase skin turnover and epidermal desquamation, removing melanized keratinocytes from the upper layers of epidermis for a more even skin colour. They significantly restore damaged skin, revealing a new skin with a healthier, brighter and younger complexion.
Depending on patient’s skin type and benefits to achieve, Doctor will prescribe the most suitable acid to enhance the depigmentation cream results:
Azelaic acid is recommended for skins with hyperpigmentations, irregular texture and acne tendency. It inhibits Tyrosinase action in the melanogenesis process, removing skin blemishes and leading to an even and luminous tone. It helps to remove post inflammatory hyperpigmentations.
Pyruvic acid is recommended for light skin phototypes (I to IV) and severe photoaged skin. With powerful effects, it substantially increase skin flaking, eliminating all skin imperfections and erasing melanic blemishes.
Mandelic acid with whitening properties, it enhances the inhibition of Tyrosinase helping to lighten skin blemishes revealing an even a smooth skin complexion. Thanks to its high molecular weight, don’t penetrate deep in skin avoiding irritation and facilitating the faster recovering of tissues treated with acids, being suitable for the treatment of sensitive skins.
To guarantee effective and lasting results it is imperative strictly follow the treatment either in the clinic as at home. Professional peel initiated at the medical office must be continued at home, on a daily basis. The daily application of the topical depigmentation cream slows and blocks de process of melanogenesis by intervening on the tyrosinase activity, stopping the dopaquinone formation, blocking dopatautomerase activity in the production of eumelanines.